Welcome to the weekend! Views Read Edit View history. Doctors providing opioids without proper documentation: My caged iris rhizomes are doing great! At least for now. This company allows you to eat healthy without all the usual hassle. Study They reported at least one suicide attempt in the last year, the study found.
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Now that cooler weather has finally moved in, I will be doing more transplanting and moving plants this weekend. Another week has gone by. So much for my goal this year to post more LOL. Othello has put out a few blooms. I have started renovating the back sunny flower bed. I need to move the taller plants into the back. So, last weekend I got a bee in my bonnet and started moving stuff. Irises have been moved up to the front.
I moved the really tall globe thistle to behind the bird bath. I think I got a bit over zealous with moving since we had super hot and muggy temps this week and it really stressed out the globe thistles:.
Another big project was digging up this mess of whatever. I had chopped it all way down in the spring and decided the stump needed to come out. That stump has to weigh 40 pounds at least. It is soooo heavy. Thinking about a rose of Sharon bush there or maybe some small tree. Labor Day is coming up and that means getting ready for fall! I had my good camera out for shots today. These look really good still in the front and the back.
It looks like some seedlings started this year. This is a miniature version, so if you have a smaller garden, it will fit in perfectly rather than the really tall ones. I still have a critter problem out in the back yard. The woodchuck was back. He left me with this nice bare spot:. I divided up some of my irises and planted those new rhizomes I got last week.
Here is my solution to keep the critters away from them:. Always something new to see when I go out there. Everywhere you read that water helps with weight loss in many ways. While the hydrated part is true — and a good thing, the others are kind of spotty.
There is a lot of anecdotal evidence where people say it helps them, but is it really true? One study had participants drinking increasing amounts of water prior to eating at a lunch buffet to see if the water had any effect. Turns out not so much — at least for overweight individuals. This was reporting on how much water a person consumed in a day versus the number of calories eaten.
Energy density of foods, servings of fruits or vegetables and eating patterns did not differ between the water and the no-water day in both men and women. For me, drinking water never really keeps me from eating. Do you find any benefits from drinking 8 glasses of water a day? Or do you try to drink 8 glasses a day? John and I have been battling the crud. John started getting sick last week and was feeling terrible. I thought i was in the clear, but Sunday I started with the sore throat.
Leaves and buds all nibbled off. I started spraying with neem and some leaves are starting to sprout again. So, I planted a couple of peonies around it that i got in a clearance sale. Superman is guarding the new peonies. This was something we found attached to our fence when we moved in and i kept it for whatever reason.
Maybe they will work. I like the plant, but if I had known it was going to get this tall, I would have it about 6 feet further back. I need to read and see if these tolerate being moved.
It obscures the path through here, too. Welcome to the weekend! We have still been having rain off and on, which has been nice for not watering the garden. I have some self-seeders coming up. These are from the seeds that drop. There are a couple of other ones as well. I guess I will just let them reseed as long as they want to come up. I had Cleome two years ago. This must have been seed that overwintered for two years! These normally are tall — or the parents were. That was fun to find.
There is one other one as well. One seed packet had different color flowers in it for some reason. There are several different colors:. I have a dwarf butterfly bush in the front and I must say, it is nice and bushy with lots of blooms coming on it. Last year I planted some flowering tobacco — an old-fashioned kind. I replanted it in the spring and now, finally, it has bloomed:. The ones in the back did. Who knows why that is. The vagaries of gardening.
Have a great one! John had a fairly laid back 50th birthday. We just did whatever he wanted for the day. I took him out for dinner at a new place called Downtown Social, which is a place that combines a restaurant, deli, bourbon room and music stage all in one. The German potato salad on the side was served in a red cabbage cup — cute! This was a tasty sandwich and I saved half of it.
It was bigger than this picture looks. He wanted this recipe from Bobby Flay. The recipe has a lot of steps including making caramel and an apple topping to go on top. A lot of work, but it was worth it! Happy Friday and happy weekend everyone! On to the blooms. I was a little surprised to see the mullein sending up more flowers. I really was not expecting these to bloom this year, so bonus!
There is something like species in the mullein family. You do find it in some herbal teas in stores. This hydrangea is now 3 years old. This is the first year that I have seen the pink and only on the largest blooms.
Maybe it just needed to be more mature. One thing about the baby birds — they are not afraid of people. The chickadees sit very close to us and I was maybe 6 feet from this guy. He just kept munching away. In fact, he ate seed the whole time we were eating our lunch outside! There was a mixture of thistle and safflower seeds in that feeder. Have a great weekend! I drink hot coffee even in warmer weather, but it just got to be too much. I was making cold brew in a pitcher, but it is kind of messy, so I bought a cold brewer:.
The grounds stay in a filter and you just pour the coffee out instead of having to strain it. The downside with cold brew is that it has to brew overnight and preferably 24 hours.
So if you forget, no cold brew LOL. Lots and lots of snapdragons: Some random blooms on the balloon flower: The new rose of Sharon bush: It seems happy in the new spot. However, as fat-soluble hormones, AAS are membrane-permeable and influence the nucleus of cells by direct action. The pharmacodynamic action of AAS begin when the exogenous hormone penetrates the membrane of the target cell and binds to an androgen receptor AR located in the cytoplasm of that cell.
From there, the compound hormone-receptor diffuses into the nucleus, where it either alters the expression of genes  or activates processes that send signals to other parts of the cell. The effect of AAS on muscle mass is caused in at least two ways: It has been hypothesized that this reduction in muscle breakdown may occur through AAS inhibiting the action of other steroid hormones called glucocorticoids that promote the breakdown of muscles. As their name suggests, AAS have two different, but overlapping, types of effects: Some examples of the anabolic effects of these hormones are increased protein synthesis from amino acids , increased appetite, increased bone remodeling and growth, and stimulation of bone marrow , which increases the production of red blood cells.
Through a number of mechanisms AAS stimulate the formation of muscle cells and hence cause an increase in the size of skeletal muscles , leading to increased strength. The androgenic effects of AAS are numerous. Depending on the length of use, the side effects of the steroid can be irreversible.
Processes affected include pubertal growth, sebaceous gland oil production, and sexuality especially in fetal development. Some examples of virilizing effects are growth of the clitoris in females and the penis in male children the adult penis size does not change due to steroids [ medical citation needed ] , increased vocal cord size, increased libido , suppression of natural sex hormones , and impaired production of sperm.
Men may develop an enlargement of breast tissue, known as gynecomastia, testicular atrophy, and a reduced sperm count. Compounds with a high ratio of androgenic to an anabolic effects are the drug of choice in androgen-replacement therapy e. This disassociation is less marked in humans, where all AAS have significant androgenic effects. A commonly used protocol for determining the androgenic: The VP weight is an indicator of the androgenic effect, while the LA weight is an indicator of the anabolic effect.
Two or more batches of rats are castrated and given no treatment and respectively some AAS of interest. Animal studies also found that fat mass was reduced, but most studies in humans failed to elucidate significant fat mass decrements.
The effects on lean body mass have been shown to be dose-dependent. Both muscle hypertrophy and the formation of new muscle fibers have been observed. The hydration of lean mass remains unaffected by AAS use, although small increments of blood volume cannot be ruled out. The upper region of the body thorax, neck, shoulders, and upper arm seems to be more susceptible for AAS than other body regions because of predominance of ARs in the upper body. After drug withdrawal, the effects fade away slowly, but may persist for more than 6—12 weeks after cessation of AAS use.
Overall, the exercise where the most significant improvements were observed is the bench press. The measurement of the dissociation between anabolic and androgenic effects among AAS is based largely on a simple although arguably unsophisticated and outdated model involving rat tissue bioassays. The intracellular metabolism theory explains how and why remarkable dissociation between anabolic and androgenic effects can occur despite the fact that these effects are mediated through the same signaling receptor, and of course why dissociation is invariably incomplete.
An animal study found that two different kinds of androgen response elements could differentially respond to testosterone and DHT upon activation of the AR. Changes in endogenous testosterone levels may also contribute to differences in myotrophic—androgenic ratio between testosterone and synthetic AAS. Testosterone can be metabolized by aromatase into estradiol , and many other AAS can be metabolized into their corresponding estrogenic metabolites as well.
The major effect of estrogenicity is gynecomastia woman-like breasts. AAS are androstane or estrane steroids. As well as others such as 1-dehydrogenation e. The most commonly employed human physiological specimen for detecting AAS usage is urine, although both blood and hair have been investigated for this purpose.
The AAS, whether of endogenous or exogenous origin, are subject to extensive hepatic biotransformation by a variety of enzymatic pathways. The primary urinary metabolites may be detectable for up to 30 days after the last use, depending on the specific agent, dose and route of administration.
A number of the drugs have common metabolic pathways, and their excretion profiles may overlap those of the endogenous steroids, making interpretation of testing results a very significant challenge to the analytical chemist. Methods for detection of the substances or their excretion products in urine specimens usually involve gas chromatography—mass spectrometry or liquid chromatography-mass spectrometry. The use of gonadal steroids pre-dates their identification and isolation.
Medical use of testicle extract began in the late 19th century while its effects on strength were still being studied. In the s, it was already known that the testes contain a more powerful androgen than androstenone , and three groups of scientists, funded by competing pharmaceutical companies in the Netherlands, Germany, and Switzerland, raced to isolate it. The chemical synthesis of testosterone was achieved in August that year, when Butenandt and G. Wettstein, announced a patent application in a paper "On the Artificial Preparation of the Testicular Hormone Testosterone Androstenoneol.
Clinical trials on humans, involving either oral doses of methyltestosterone or injections of testosterone propionate , began as early as Kennedy was administered steroids both before and during his presidency.
The development of muscle-building properties of testosterone was pursued in the s, in the Soviet Union and in Eastern Bloc countries such as East Germany, where steroid programs were used to enhance the performance of Olympic and other amateur weight lifters.
In response to the success of Russian weightlifters, the U. The new steroid was approved for use in the U.
It was most commonly administered to burn victims and the elderly. The drug's off-label users were mostly bodybuilders and weight lifters.
Although Ziegler prescribed only small doses to athletes, he soon discovered that those having abused Dianabol suffered from enlarged prostates and atrophied testes.
Three major ideas governed modifications of testosterone into a multitude of AAS: Androgens were discovered in the s and were characterized as having effects described as androgenic i. Although anabolic steroid was originally intended to specifically describe testosterone-derived steroids with a marked dissociation of anabolic and androgenic effect, it is applied today indiscriminately to all steroids with AR agonism-based anabolic effects regardless of their androgenic potency, including even non-synthetic steroids like testosterone itself.
The legal status of AAS varies from country to country: Unlawful distribution or possession with intent to distribute AAS as a first offense is punished by up to ten years in prison. Those guilty of buying or selling AAS in Canada can be imprisoned for up to 18 months. In Canada, researchers have concluded that steroid use among student athletes is extremely widespread. A study conducted in by the Canadian Centre for Drug-Free Sport found that nearly 83, Canadians between the ages of 11 and 18 use steroids.
AAS are readily available without a prescription in some countries such as Mexico and Thailand. The history of the U. The same act also introduced more stringent controls with higher criminal penalties for offenses involving the illegal distribution of AAS and human growth hormone. By the early s, after AAS were scheduled in the U.
In the Controlled Substances Act, AAS are defined to be any drug or hormonal substance chemically and pharmacologically related to testosterone other than estrogens , progestins , and corticosteroids that promote muscle growth. The act was amended by the Anabolic Steroid Control Act of , which added prohormones to the list of controlled substances , with effect from January 20, In the United Kingdom, AAS are classified as class C drugs for their illegal abuse potential, which puts them in the same class as benzodiazepines.
Part 1 drugs are subject to full import and export controls with possession being an offence without an appropriate prescription. There is no restriction on the possession when it is part of a medicinal product.
Part 2 drugs require a Home Office licence for importation and export unless the substance is in the form of a medicinal product and is for self-administration by a person.
Many other countries have similar legislation prohibiting AAS in sports including Denmark,  France,  the Netherlands  and Sweden. United States federal law enforcement officials have expressed concern about AAS use by police officers. It's not that we set out to target cops, but when we're in the middle of an active investigation into steroids, there have been quite a few cases that have led back to police officers," says Lawrence Payne, a spokesman for the United States Drug Enforcement Administration.
Following the murder-suicide of Chris Benoit in , the Oversight and Government Reform Committee investigated steroid usage in the wrestling industry.
The documents stated that 75 wrestlers—roughly 40 percent—had tested positive for drug use since , most commonly for steroids. AAS are frequently produced in pharmaceutical laboratories, but, in nations where stricter laws are present, they are also produced in small home-made underground laboratories, usually from raw substances imported from abroad. As with most significant smuggling operations, organized crime is involved. In the late s, the worldwide trade in illicit AAS increased significantly, and authorities announced record captures on three continents.
In , Finnish authorities announced a record seizure of A year later, the DEA seized In the first three months of , Australian customs reported a record seizures of AAS shipments. Illegal AAS are sometimes sold at gyms and competitions, and through the mail, but may also be obtained through pharmacists, veterinarians, and physicians.
AAS, alone and in combination with progestogens , have been studied as potential male hormonal contraceptives. From Wikipedia, the free encyclopedia. This article is about androgens as medications. For androgens as natural hormones, see Androgen. Ergogenic use of anabolic steroids. Use of performance-enhancing drugs in sport.
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